Magnesium Monograph

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Abstract Although American diets generally do not contain adequate amounts of magnesium,1 physiological magnesium deficiencies are more likely to occur in those on diuretics or high sodium diets,2 with malabsorption syndromes,3 or with diabetes.4 Because magnesium plays such a diverse and essential role in human physiology, subclinical magnesium deficiency can manifest in symptoms such as fatigue and muscle weakness.3 Magnesium deficits can also exacerbate an already existing disease state or increase the risk of complications in specific conditions, including diabetes, cardiovascular conditions, renal stones, osteoporosis, hypertension, preeclampsia, and asthma. Magnesium exists mostly as an intracellular cation with 99 percent of body stores in intracellular spaces. Approximately 66 percent is found in bone, and 33 percent in cardiac muscle, skeletal muscle, and liver.3
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