Cluster headache, nicknamed "suicide headache", is a neurological disease that involves, as its most prominent feature, an immense degree of pain. "Cluster" refers to the tendency of these headaches to occur periodically, with active periods interrupted by spontaneous remissions. The cause of the disease is currently unknown.
Overview of Cluster Headaches
Elizabeth Leroux and Anne Ducros
Centre d'Urgences Céphalées, Hôpital Lariboisière, Paris, France
Orphanet Journal of Rare Diseases 2008, 3:20doi:10.1186/1750-1172-3-20 Published: 23 July 2008
© 2008 Leroux and Ducros; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cluster headache (CH) is a primary headache disease characterized by recurrent short-lasting attacks (15 to 180 minutes) of excruciating unilateral periorbital pain accompanied by ipsilateral autonomic signs (lacrimation, nasal congestion, ptosis, miosis, lid edema, redness of the eye). It affects young adults, predominantly males. Prevalence is estimated at 0.5–1.0/1,000. Cluster Headache has a circannual and circadian periodicity, attacks being clustered (hence the name) in bouts that can occur during specific months of the year. Alcohol is the only dietary trigger of Cluster Headaches, strong odors (mainly solvents and cigarette smoke) and napping may also trigger Cluster Headache attacks. During bouts, attacks may happen at precise hours, especially during the night. During the attacks, patients tend to be restless. Cluster Headaches may be episodic or chronic, depending on the presence of remission periods. Cluster Headache is associated with trigeminovascular activation and neuroendocrine and vegetative disturbances, however, the precise cautive mechanisms remain unknown. Involvement of the hypothalamus (a structure regulating endocrine function and sleep-wake rhythms) has been confirmed, explaining, at least in part, the cyclic aspects of Cluster Headaches. The disease is familial in about 10% of cases. Genetic factors play a role in Cluster Headache susceptibility, and a causative role has been suggested for the hypocretin receptor gene. Diagnosis is clinical. Differential diagnoses include other primary headache diseases such as migraine, paroxysmal hemicrania and SUNCT syndrome. At present, there is no curative treatment. There are efficient treatments to shorten the painful attacks (acute treatments) and to reduce the number of daily attacks (prophylactic treatments). Acute treatment is based on subcutaneous administration of sumatriptan and high-flow oxygen. Verapamil, lithium, methysergide, prednisone, greater occipital nerve blocks and topiramate may be used for prophylaxis. In refractory cases, deep-brain stimulation of the hypothalamus and greater occipital nerve stimulators have been tried in experimental settings. The disease course over a lifetime is unpredictable. Some patients have only one period of attacks, while in others the disease evolves from episodic to chronic form.
Disease name and synonyms
Other terms for cluster headache (CH) are erythroprosopalgia, ciliary or migrainous neuralgia, erythromelalgia of the head, Horton's headache, histaminic cephalalgia, petrosal neuralgia of Gardner, sphenopalatine, Vidian and Sluder's neuralgia, and hemicrania periodica neuralgiformis. In French, it is named algie vasculaire de la face, somewhat a misnomer since Cluster Headache does not primarily involve a dysfunction of arteries or veins.
Definition, diagnostic criteria and forms
Cluster headache is a primary headache disease like migraine or tension-type headache. By contrast to secondary headaches, in which the pain is symptomatic of an underlying brain, cranial or systemic disorder, primary headaches are due to spontaneous activation of nociceptive pathways. Cluster Headache is characterized by recurrent attacks of short-lasting excruciating pain accompanied by signs of autonomic dysfunction, as described in the second version of the International Classification Headaches second edition (ICHD-II) criteria presented in table 1. The patient must have had at least five attacks of severe or very severe unilateral orbital or supraorbital and/or temporal pain, lasting 15 to 180 minutes if untreated. The headache is accompanied by one ipsilateral autonomic symptom among the following: conjunctival injection and lacrimation, nasal congestion or rhinorrhea, forehead and facial sweating, eyelid edema, miosis and ptosis. In the absence of autonomic signs, Cluster Headaches can be diagnosed if a sense of restlessness or agitation is present during the attacks.
Diagnostic criteria for cluster headache according to the International Classification of Headache Diseases II 3.1 Cluster headache
A. At least five attacks fulfilling B through D
B. Severe or very severe unilateral orbital, supraorbital and/or temporal pain lasting 15 to 180 minutes if untreated
C. Headache is accompanied by at least one of the following:
1. Ipsilateral conjunctival injection and/or lacrimation
2. Ipsilateral nasal congestion and/or rhinorrhea
3. Ipsilateral eyelid edema
4. Ipsilateral forehead and facial sweating
5. Ipsilateral miosis and/or ptosis
6. A sense of restlessness or agitation
D. Attacks have a frequency from one every other day to eight per day
E. Not attributed to another disorder
Cluster Headache is the most common type of the trigeminal autonomic cephalalgias (TACs), which include paroxysmal hemicrania and SUNCT (Short Unilateral Neuralgiform headache with Conjunctival injection and Tearing). It is divided in episodic and chronic forms , as detailed in table 2. In 80% of cases, the disease is episodic and may present with one or two periods per year, or even may go into remission for many years before development of another cluster period. In about 20% of CH patients the disease is chronic . These patients have ongoing attacks for one year or more, without more than one month of remission. These refractory patients are difficult to diagnose and manage, and need to be referred to a headache specialist.
ICHD-II criteria for episodic and chronic cluster headache 3.1.1 Episodic cluster headache
A. All fulfilling criteria A through E of 3.1
B. At least two cluster periods lasting from 7 to 365 days and separated by pain free remissions of > 1 month.
The prevalence of Cluster Headaches can be estimated at approximately 0,5 – 1.0/1,000 [3-12]. Table 3 summarizes the epidemiological studies on Cluster Headaches. Many of these studies are biased by the sample chosen and by the difficulties of diagnosing Cluster Headache by mailed questionnaires or telephone interviews. In a tertiary care headache clinic, Cluster Headache was diagnosed in 2.73% of patients. There is a clear male predominance in Cluster Headaches, but it has been estimated to be decreasing over the years , maybe due to increased recognition of the disease in women . Cluster Headache is a condition affecting young adults, first attacks usually occurring in the third decade. It is probably under-diagnosed and unrecognized; a significant diagnostic delay has been reported in most patients [15,16]. Cluster Headache in children is rare, but a few cases have been reported , the youngest patients being three years old . Symptoms often decrease after age of 70 years. Heavy smoking has been frequently documented amongst Cluster Headache patients .
Epidemiological studies of cluster headache
Duration and frequency of attacks
Cluster headache attacks are unilateral, severe, short-lasting (15 to 180 minutes) and recurrent (1 every other day to 8 per day) . This special pattern is very important to recognize the cluster headaches and to differentiate them from migraine attacks. A patient describing a pain lasting less than three hours, severe and localized on one side of the head, coming back at specific times of the day or during sleep, must be asked if symptoms like tearing, eye swelling and nasal congestion are present on the other side. The fact that the attack ends after one or two hours must not be attributed to a success of standard analgesics, which are not useful in Cluster Headache.
A prospective study on clinical characteristics of Cluster Headache has been published by Bahra et al. . Pain is described mostly in the first trigeminal branch territory, on one side of the head only and almost always the same side (rarely, attacks may switch the location). Pain may be centered on the eye but may also be periorbital and temporal, sometimes extending to the maxillary, ear or even occipito-cervical region. Some patients describe the pain as radiating to the teeth, thus they may first consult a dentist. As to its severity, Cluster Headache is one of the most painful conditions known to man (worse than giving birth according to female patients). It is described as excruciating and intolerable. Patients compare it to a white-hot needle or knife being pushed into the eye, the eye being crushed or ripped of the orbit. Suicidal ideations may be expressed during the attacks. The nickname of the Cluster Headache among patients is "The Beast", a term suggesting an animal hiding in the shadow, attacking in a terrible and unpredictable way. Pain rises abruptly over a few minutes. It also ends rapidly. In severe chronic forms or in episodic forms with numerous daily attacks, there may be a continuous discomfort on the affected side , but usually Cluster Headache patients are completely asymptomatic between attacks.
Parasympathetic hyperactivity signs include ipsilateral lacrimation, redness of the eye and nasal congestion. The affected side of the face may be red and sweaty. Sympathetic hypoactivity is demonstrated by the combination of ipsilateral ptosis and miosis (droopy eye and smaller pupil on the affected side) during attacks. The combination of ptosis and miosis on one side is called Claude-Bernard-Horner syndrome (CBH). Persistence of CBH signs after the end of the attack in episodic Cluster Headaches should alert the clinician to suspect underlying lesion in hypothalamus, brainstem, paravertebral sympathetic chain or carotid. Proper investigations should be undertaken: brain magnetic resonance imaging (MRI), chest computerized tomography and carotid ultrasound.
Autonomic signs are very prominent in certain patients, but may be subtle or even absent in 3% of patients . They can be unrecognized because of the pain ("I close my eye, I cry because I'm in pain"). In case of uncertainty, the patient can be asked to observe these specific signs during the attack.
Physical activity seems to partially alleviate the pain in Cluster Headaches. During the attacks, patients tend to be restless. They may rock from side to side, hit their heads, hit objects with the fist, or even hit their head against the wall . This behavior is so typical of Cluster Headache that it is accepted as an official criterion in the ICHD-II . Indeed, it is possible to diagnose Cluster Headache without any dysautonomic sign if the behavioral criterion is satisfied. This restless attitude may help to differentiate Cluster Headache from migraine, where patients are quiet and avoid any movement. Cluster Headache patients are cognitively alert, but may also be irritable and aggressive. There is no mental slowing or fatigue, as it may be seen in migraine patients.
Cluster Headache shows circannual and circadian cyclicity. Peaks have been described around solstices, in relation to changes in daylight duration . Attacks can happen at a precise time during the sleeping cycle, with dramatic regularity reported by patients. This cyclicity is not observed in all Cluster Headache patients and is not included in the ICHD-II criteria, though most experts find it very suggestive of Cluster Headache when present.
Alcohol is recognized as the only dietary trigger of Cluster Headache. Nitroglycerin has been used to trigger attacks for diagnostic purpose (therefore, e nitrates should be avoided during bouts). Strong odors (mainly solvents and cigarette smoke) and napping may trigger Cluster Headache attacks. It is surprising that all triggers are effective only during bouts. In between periods, patients may smoke and drink alcohol without triggering attacks.
There is a significant delay in diagnosing Cluster Headache (reported median delay of three years ), though there is an improvement as compared to the 1960's when a diagnostic delay of more than 20 years was not infrequent . Up to 30% of patients have previously undergone many investigations and seen dentists, ENT (ears, nose, throat) surgeons, ophthalmologists, even neurologists, without being diagnosed. Up to 16% may have undergone dental, sinus or eye surgery . The periodicity of attacks makes the diagnosis difficult and sometimes suggests an infectious cause. Prednisone can be prescribed for sinusitis and have a positive effect, falsely confirming an erroneous diagnosis. Some patients do not seek medical advice once the bout has ended by itself.
Though aura is not frequent in Cluster Headache , up to 14% of patients report aura symptoms, with transient visual, motor or sensory disturbances preceding the facial pain . In chronic Cluster Headaches, auras have been reported in 20% of patients . Nausea, vomiting, photophobia and phonophobia can be observed in approximately 50% of patients, and must not discard the diagnosis of Cluster Headaches if other criteria are fulfilled. A shift of the affected side may be observed within a bout or between two bouts in 15% of patients . Case reports of "CH sine headache" have described patients with episodes of unilateral facial autonomic dysfunction without pain [25,26], but this is very rare.
Etiology: a role for the hypothalamus, but many uncertainties
The exact cause of Cluster Headaches is currently unknown. The first hypotheses on Cluster Headaches, inspired by the effects of vasoactive substances in Cluster Headache (dilators causing attacks, constrictors ending them) were based on the neurovascular theory. An initial dysfunction or inflammation of the blood vessels in the parasellar or cavernous sinus area would activate the orbital trigeminal pain pathways. Indeed, activation of the trigeminal-vascular system is present, but whether it is a cause or consequence of Cluster Headache is not clear. It is not specific for Cluster Headache, since it is also very prominent, and much better demonstrated, in migraine. Later on, the periodicity of Cluster Headache has oriented studies toward the hypothalamus, with more fruitful results. Positron emission tomography (PET) studies have show an activation of the posterior hypothalamus during Cluster Headache attacks , reinforcing the idea that the hypothalamus may be the Cluster Headache generator. Voxel-based morphometry studies demonstrated an increase in the gray matter volume of the posterior hypothalamus in Cluster Headache patients compared to controls . Success of hypothalamic deep-brain stimulation (DBS)  and emerging evidence for hypocretin receptor gene involvement also strengthen that hypothesis. Abnormal blood levels of prolactin, testosterone, thyroid stimulating hormone (TSH), and cortisol may be linked to perturbations in the activity of the hypothalamic-pituitary-adrenal axis.
Numerous studies have examined blood levels of other substances in Cluster Headache patients during attacks, bouts and remissions. Histamine, prostaglandins, opiates, neuropeptids, amines, nitric oxide, monoamine oxydase, serotonin and cytokines values may show significant differences compared to those in non-affected controls. The list is long but, so far, none of these studies allowed a coherent understanding of Cluster Headaches. The parasympathetic activation is thought to be mediated by the trigeminal-autonomic reflex in the brainstem circuitry,via the seventh cranial nerve. The sympathetic innervation pathway to the pupil and eyelid is composed of three neurons and there is no clear demonstration of the site involved and mechanisms underlying the dysfunction in Cluster Headache. The reason for the male predominance of Cluster Headaches also remains to be clarified.
Initially, Cluster Headache was not thought to be a genetic disease. With official criteria published and the increasing recognition of the disease, a genetic aspect of Cluster Headache has been identified. Cases of twin pairs affected by Cluster Headache have been published [30-32]. Studies using large twin registries have shown that monozygotic twins present a higher concordance rate for Cluster Headache (2/12 pairs) than dizygotic twins (0/25 pairs), indicating the existence of genetic factors, but monozygotic twins can also be concordant or discordant for Cluster Headache, confirming a role for environmental factors [11,33]. Family studies of Cluster Headache patients' cohorts have shown a familial aggregation in 7% to 20% of patients, and a relative risk for first-degree relatives between 14 and 39 [34-36]. The transmission mode has still not been established. Some studies have suggested an autosomal dominant way with incomplete penetrance , while other described an autosomal recessive transmission . So far, no X-linked pedigrees have been published. No susceptibility locus has been identified. Much work has recently been done on the HCRTR2 gene (hypocretin receptor 2) polymorphism [39,40], suggesting a role of this gene in Cluster Headache susceptibility. Hypocretins are secreted in the hypothalamus, a structure clearly involved in Cluster Headache. All these findings suggest that genetic factors do play a role in Cluster Headache [41,42], though, so far, the transmission mode remains to be established and the contribution of individual factors to be clearly understood. The HCRTR2 gene is a promising research area.
Diagnosis of cluster headache is based on clinical criteria and exclusion of a secondary cause. A first attack suggestive of Cluster Headaches must always be thoroughly investigated, and carotid dissection has to be properly excluded either with doppler ultrasound or angio-scanner and magnetic resonance angiography of the neck vessels . When the history is typical with numerous periods, attacks and no interictal abnormalities on neurological examination, MRI is not mandatory. Imaging studies in Cluster Headache patients are most of the time normal, but lesions can be detected in secondary cases. An association with pituitary tumors has been suspected . Any refractory case should undergo MRI study to exclude a treatable cause. The pituitary, orbit, and trigeminal pathway have to be specifically examined with computed tomography (CT) and MRI.
Primary headache diseases
The only way to differentiate Cluster Headache from migraine is the clinical history. The questionnaire is of paramount importance. The global picture must be taken into account. In case of doubt, further observation of attacks by the patient is warranted. Migraine and CH are both very incapacitating and share common features, but they also differ on specific points. Migraine is much more frequent than Cluster Headache (15% of the general population versus 0.05%–0.1%), affects mainly women, and starts earlier in life, often during adolescence or around menarche. Migraine attacks occur at regular intervals over months, without long remission periods, though in some patients seasonal triggers may cause more frequent attacks (allergies, stress). Migraine attacks last longer (more than four hours and can go on for more than 24 hours) . Attacks may have a prodrome with hunger, fatigue, irritability, and start more progressively. Patients tend to stay quiet and avoid any movement. The pain may begin unilaterally but during the attack it may radiate to the whole head. Many patients have attacks on alternate sides. Pain is moderate-to-severe, but is not described as intolerable or excruciating. The presence of nausea and/or photophobia and phonophobia is a main clinical criterium , but it is not specific for migraine, as Cluster Headache can also be accompanied by nausea, photophobia and phonophobia in up to 50% of patients . Unilateral photo- and phonophobia may be more specific of Cluster Headaches and trigeminal autonomic cephalalgias in general . In up to 30% of patients with migraine, autonomic signs like lacrimation and nasal congestion are present. Both Cluster Headache and migraine can be triggered by alcohol, and relieved by triptans, but Cluster Headache necessitates parenteral routes of administration. Stress, foods (like chocolate) and menstrual cycle, are not typical triggers for Cluster Headaches. Finally, some cases are difficult to diagnose and should be referred to a headache specialist. In some patients, Cluster Headache and migraine can coexist, and treatment must be chosen accordingly. Table 4 presents a clinical comparison of Cluster Headache and migraine.
Table 4. Comparison of migraine and cluster headache
Other trigeminal autonomic cephalalgias (TACs)
Paroxysmal hemicrania (PH) is more frequent in women (80–90%) and differs from Cluster Headache by the shorter length and higher frequency of attacks [46-48]. Absolute response to an adequate dose of indomethacin (150 mg per day or more) confirm the diagnosis of PH . A continuum between paroxysmal hemicrania and Cluster Headache has been suggested by some authors, due to an overlap in clinical criteria and anecdotal reports of Cluster Headache patients responding to indomethacin. Indomethacin treatment in any refractory case of Cluster Headache, or cases with frequent and shorter attacks, has been suggested by Matharu and Goatsby .
SUNCT syndrome is a very rare entity . Its prevalence is estimated around 6,6 per 100,000 . Attacks are very short and occur up to 300 times a day.
Hemicrania continua may be confused with chronic cluster headache, and if there is a doubt, a trial with indomethacin should be made, HC being highly responsive to this drug [52,53]. Table 5 presents the main characteristics of TACs.
Table 5. Trigeminal-autonomic cephalalgias (TACs)
Other ICHD-II categories
Trigeminal neuralgia (TN) and Cluster Headache both involve paroxysms of unilateral and severe pain, but specific traits are found on the questionnaire . TN is more frequent in women in their fifties or older. Attacks are centered on maxillary and/or mandibular area, they are more frequent, briefer, electric-like and are triggered by touching specific zones of the face or buccal cavity. Eating, laughing, talking, shaving or brushing the teeth may all trigger the shocks. Patients may loose weight because they avoid eating. There is no clustering in periods, and mostly the pain goes on until the treatment starts. TN responds very well to carbamazepine. Both diseases may occur in the same patient as cluster-tic (tic standing for tic douloureux, a French term). Table 6 summarizes the clinical manifestations helping to distinguish TN from CH.
Table 6. Comparison of cluster headache and trigeminal neuralgia
In an elderly patient with exclusively nocturnal attacks, hypnic headache may be diagnosed, but it is very rare and pain is usually bilateral, diffuse and without autonomic signs. Attacks occur exclusively during sleep .
In doubt, the clinician may ask the patient to complete a diary of the attacks, to precise their duration, autonomic symptoms, triggers, response to treatment, and daily cyclicity. The importance of history taking in headache medicine cannot be overemphasized.
Causes of symptomatic Cluster Headaches
Features suggesting a secondary Cluster Headaches are: persistent or worsening pain, abnormal signs on neurological examination, and a first period after 50 years old. An underlying cause has sometimes been found in a patient with typical Cluster Headache features [55,56]. Benign intracranial tumors like meningiomas and neurinomas, but also carcinomas and metastases, have been reported. There seems to be an overrepresentation of pituitary tumors in Cluster Headache patients , and a role of prolactin has been suggested in these cases. Orbital tumors or infections have been reported. Sinusitis may present with symptoms typical for Cluster Headache. Arteriovenous malformations and aneurysms, if strategically located, may cause Cluster Headache symptoms. In a first episode, carotid dissection has to be suspected and ruled out (it also can produce Claude-Bernard-Horner syndrome, and the pain may respond to triptans) . Any case of refractory Cluster Headache deserves a brain MRI. Some experts even recommend MRI for every Cluster Headache patient, to avoid unnecessary treatments if a treatable cause is found.
As familial cluster headache is rare, thus, considering the limited knowledge on the genes involved and the transmission mode, genetic counseling is not routinely part of the Cluster Headache management. Familial cases should be identified and, if possible, the family referred to a specialist in cluster headache. There is no known preventive treatment for Cluster Headaches, or curative intervention, but affected patients may inform their families of the Cluster Headache symptoms, thus any delay in diagnosis among relatives to be avoided. Antenatal diagnosis is not applicable
Acute treatments are efficient to alleviate pain during attacks. Prophylactic treatments aim at reducing the daily number of attacks. No curative treatment for Cluster Headache is currently available. Guidelines (evidence-based recommendations and good practice points) for the treatment of Cluster Headaches are developed by the European Federation of Neurological Societies (EFNS) .
Acute management of attacks
Because of the excruciating character of the pain, rapid-acting treatments are preferred for acute management of attacks . The oral route of administration is too slow and is rarely used. Inhaled, subcutaneous and intra-nasal treatments are preferred. The pain in Cluster Headache is often underestimated by the medical community. Interictally, patients appear normal. In most cases, witnessing a Cluster Headache attack is convincing enough, but not possible for every practitioner. Adequate treatments must be provided, and a nihilistic, observational approach should be absolutely avoided.
The two most efficient acute treatments are subcutaneous sumatriptan and high-flow inhaled oxygen.
Sumatriptan is a serotonin 5HT1 B/D agonist, acting on blood vessels with a vasoconstricting effect, and centrally on brainstem receptors. Subcutaneous sumatriptan 6 mg (Imiject, Imitrex) has been shown to efficiently relieve the Cluster Headache pain and dramatically improve the management of patients . After the injection, the patient may feel a rush of heat and chest tightness that disappear in a few minutes and are followed by rapid relief of the pain. Intra-nasal sumatriptan [61,62] and zolmitriptan  may be tried if patients refuse to use injections. Absolute contra-indications to subcutaneous sumatriptan include pregnancy, lactation, coronary artery disease, stroke, and peripheral artery disease. Relative contra-indications are age (under 18 or over 65), an isolated controlled vascular risk factor, Raynaud phenomenon, allergy to sulfa medications, treatment with a serotonin recapture inhibitor (SSRI). Maximal doses for 24 h period (sumatriptan 12 mg subcutaneous or 40 mg intra-nasal, zolmitriptan 10 mg intra-nasal) have to be explained to the patient to avoid dangerous side effects, such as coronary or distal artery spasm. Surprisingly, Cluster Headache patients do not develop medication-overuse headache (MOH) with triptans as often as migrainers do . They may use regular sumatriptan for many months without developing a different type of headache. As MOH is more frequent in Cluster Headache patients with a history/diagnosis of migraine, these patients must be carefully monitored for MOH, especially if Cluster Headache is chronic and refractory .
Inhaled oxygen with high-flow (10 to 15 l per minute) 100% normobaric oxygen breathed through a mask is efficient and useful especially when contra-indications to triptans exist [66,67]. The device is not easy to carry around, and not always reimbursed by health security services, depending on the country. The efficacy of oxygen has been recently re-examined and confirmed. There are no contra-indications or limitations for the use of oxygen.
Ergotamine and dihydroergotamine have been used in Cluster Headache . They must not be combined with triptans on the same 24 hour period, have the same contra-indications as triptans (without additional efficacy), therefore are rarely useful.
Intra-nasal application of topical lidocaine may be tried in refractory Cluster Headache cases or in case of contra-indications to triptans. Its efficacy is not well proven.
Topic cocaine was used in the past, but abandoned because of equivocal efficacy, side-effects and risks of dependency.
The aim of prophylactic treatment is to reduce the frequency of attacks during the bout. Continuous use of prophylactic treatments in episodic Cluster Headache is not recommended, since there is no proof that it prevents the next bout. Therefore, the dose may be progressively decreased after two or three months, or after the usual known duration of the bout. The prophylactic treatment should be restarted if attacks reappear. In patients with few attacks per week responding to acute treatment, prophylactic treatment can be withheld. In chronic Cluster Headache, treatments are used for a long term epriod, and a low attack rate has to be reached (always considering the potentially serious and incapacitating side effects).
The calcium-channel blocker verapamil remains the main treatment of episodic and chronic Cluster Headache [69,70]. Doses range from 360 mg to 960 mg per day, and the maximal tolerated dose should be reached before concluding about efficacy. Side effects are weakness, fatigue, lower extremities edema, and conduction heart block. An electrocardiogram should be performed at the baseline and for every increase in the dose when it exceeds 480 mg per day .
Greater occipital nerve blocks are used, based on the connection between this nerve and the trigeminal circuitry . One randomized study showed that this technique may end a bout, or, at least, may diminish the number of attacks per day . More evidence is needed to recommend this procedure , but it is widely used by experts [75,76]. The block is performed with a long-acting injectable steroid, sometimes combined with a local anesthetic. Different combinations have been described. The needle is inserted midway between the mastoid and the occipital protuberance, until it touches the occipital bone (sub occipital technique).
Topiramate has shown a convincing efficacy in CH [77,78]. Usual dosing is 100 mg per day (range 25 mg to 200 mg). Side effects include numbness and tingling in the extremities, weight loss, and neuro-cognitive difficulties, all reversible after drug discontinuation.
Lithium is used in chronic Cluster Headache [69,79,80]. Doses range from 600 to 1200 mg per day. Blood levels must not exceed 0,9 mEq per liter, and thyroid and renal function must be monitored. Side effects include tremors, insomnia, fatigue, nausea and blurred vision. Intoxication may be severe and has to be suspected quickly if nausea, confusion, rigidity and difficulty to walk appear. Because of these side effects, lithium is used sparingly, in selected cases only.
A short course of decreasing-dose prednisone (starting at 1 mg/kg) may be used to treat a bout refractory to verapamil (however, recurrence is frequent with the decrease of the dose). Long-term side effects of corticotherapy restrict the use of prednisone in chronic Cluster Headache.
Methysergide acts on serotonin receptors. Doses range from 6 to 12 mg per day. Some patients do respond very well to this drug but a major limitation is that triptans and ergots cannot be used simultaneously because of the risk of serotoninergic syndrome. The main side effect is nausea, sometimes severe. Methysergide can be considered if oxygen alone is used as an acute treatment. The main complication is retroperitoneal, pulmonary or cardiac fibrosis after prolonged use. This mandates one-month drug-holiday after six months of use, then methysergide can be started again. Methysergide is not available in United States.
Valproic acid , pizotifen, gabapentin [82,83], baclofen , and melatonin [85,86] have shown some effect in Cluster Headache prophylaxis and may be used in selected patients as a second-line therapy.
Destructive approaches like trigeminal section, thermocoagulation of gasserian ganglion, glycerol rhizotomy [87,88] and radiosurgery [89-92] of the trigeminal nerve have shown variable results and irreversible complications like anesthesia dolorosa.
Hypothalamic deep-brain stimulation (hDBS) has shown a convincing benefit in some refractory patients in series totalizing a few dozens of cases [93-96], but can be completely inefficient, and has potential serious complications. Its mechanism is not well understood and no controlled studies are available.
Neurostimulation of the greater occipital nerve has recently been described [76,99-101]. It is less invasive than DBS but costly; its long-term effects are unknown.
Non-pharmacological approaches like massotherapy, physiotherapy and acupuncture have not been adequately studied in Cluster Headache.
Cluster Headache has a very unpredictable course. Some patients have only one period of attacks, while in others the disease evolves from episodic to chronic form. There are no known factors for chronicization of the Cluster Headache. Total remission of the disease has been described. With aging, attacks often decrease and active Cluster Headache is rarely seen after age of 75 years.
Cluster Headache is a primary trigeminal-autonomic cephalalgia responsible for recurrent unilateral short-lasting attacks of excruciating orbitotemporal pain. The cause of cluster headache is not known and there is no unifying hypothesis to explain all the clinical particularities of this disease. About 10% of Cluster Headache patients have a familial form and the existence of genetic factors has been confirmed. The hypocretin receptor gene may be involved, but implication of other genes can't be excluded. In the absence of any radiological or biological marker, diagnosis relies upon clinical history. Patients are often misdiagnosed as having secondary headaches due to sinus, dental or eye disorders or as having migraine, leading to inadequate management. No curative treatment currently exists, however efficient treatment do exist to shorten painful attacks (acute treatments) and to reduce the number of daily attacks (prophylactic treatments). Ongoing research is very active. Deep-brain stimulation and occipital nerve stimulators are promising options for refractory patients but are used currently in an experimental setting. The current pathophysiological focus is on the hypothalamus. The combination of imaging techniques and genetic studies may help us to better understand this terrible and fascinating condition, ultimately leading to improvement of the care and quality of life of these patients.
CH: cluster headache; ICHD-II: International Classification Headaches second edition; TAC: trigeminal-autonomic cephalalgia; SUNCT: Short Unilateral Neuralgiform headache with Conjunctival injection and Tearing; CBH: Claude-Bernard-Horner syndrome; HCRTR2 gene: hypocretin receptor 2 gene; MRI: magnetic resonance imaging; ENT: ears, nose, throat; PET: positron emission tomography; hDBS: hypothalamic deep-brain stimulation; TSH: thyroid stimulating hormone; PH: paroxysmal hemicrania; EFNS: European Federation of Neurological Societies; SSRI: serotonin recapture inhibitor; MOH: medication-overuse headache.
The authors declare that they have no competing interests.
The two authors equally contributed to this review article. They read and approved the final version of the manuscript.
The International Classification of Headache Disorders
Cephalalgia 2nd edition. 2004 , 24(Suppl 1):9-160.
Bahra A, May A, Goadsby PJ: Cluster headache: a prospective clinical study with diagnostic implications.
Neurology 2002 , 58:354-361.
D'Alessandro R, Gamberini G, Benassi G, Morganti G, Cortelli P, Lugaresi E: Cluster headache in the Republic of San Marino.
Cephalalgia 1986 , 6:159-162.
Katsarava Z, Obermann M, Yoon MS, Dommes P, Kuznetsova J, Weimar C, Diener HC: Prevalence of cluster headache in a population-based sample in Germany.
Cephalalgia 2007 , 27:1014-1019.
Epub 2007 Jul 1030
Sjaastad O, Bakketeig LS: Cluster headache prevalence. Vaga study of headache epidemiology.
Cephalalgia 2003 , 23:528-533.
Swanson JW, Yanagihara T, Stang PE, O'Fallon WM, Beard CM, Melton LJ 3rd, Guess HA: Incidence of cluster headaches: a population-based study in Olmsted County, Minnesota.
Neurology 1994 , 44:433-437.
Tonon C, Guttmann S, Volpini M, Naccarato S, Cortelli P, D'Alessandro R: Prevalence and incidence of cluster headache in the Republic of San Marino.
Neurology 2002 , 58:1407-1409.
Torelli P, Beghi E, Manzoni GC: Cluster headache prevalence in the Italian general population.
Neurology 2005 , 64:469-474.
Torelli P, Castellini P, Cucurachi L, Devetak M, Lambru G, Manzoni GC: Cluster headache prevalence: methodological considerations. A review of the literature.
Acta Biomed 2006 , 77:4-9.
Ekbom K, Ahlborg B, Schele R: Prevalence of migraine and cluster headache in Swedish men of 18.
Headache 1978 , 18:9-19.
Ekbom K, Svensson DA, Pedersen NL, Waldenlind E: Lifetime prevalence and concordance risk of cluster headache in the Swedish twin population.
Neurology 2006 , 67:798-803.
Evers S, Fischera M, May A, Berger K: Prevalence of cluster headache in Germany: results of the epidemiological DMKG study.
J Neurol Neurosurg Psychiatry 2007 , 78:1289-1290.
Manzoni GC: Male preponderance of cluster headache is progressively decreasing over the years.
Headache 1997 , 37:588-589.
Broner SW, Sun-Edelstein C, Lay CL: Cluster headache in women.
Curr Pain Headache Rep 2007 , 11:127-130.
Bahra A, Goadsby PJ: Diagnostic delays and mis-management in cluster headache.
Acta Neurol Scand 2004 , 109:175-179.
van Vliet JA, Eekers PJ, Haan J, Ferrari MD: Features involved in the diagnostic delay of cluster headache.
J Neurol Neurosurg Psychiatry 2003 , 74:1123-1125.
Lampl C: Childhood-onset cluster headache.
Pediatr Neurol 2002 , 27:138-140.
Garrido C, Tuna A, Ramos S, Temudo T: [Cluster headache in a 3 year old child].
Rev Neurol 2001 , 33:732-735.
Cirillo M, Stellato D, Lombardi C, De Santo NG, Covelli V: Headache and cardiovascular risk factors: positive association with hypertension.
Headache 1999 , 39:409-416.
Donnet A, Lanteri-Minet M, Guegan-Massardier E, Mick G, Fabre N, Geraud G, Lucas C, Navez M, Valade D: Chronic cluster headache: a French clinical descriptive study.
J Neurol Neurosurg Psychiatry 2007 , 78:1354-1358.
Epub 2007 Apr 1318
Ekbom K: Evaluation of clinical criteria for cluster headache with special reference to the classification of the International Headache Society.
Cephalalgia 1990 , 10:195-197.
Torelli P, Manzoni GC: Pain and behaviour in cluster headache. A prospective study and review of the literature.
Funct Neurol 2003 , 18:205-210.
Kudrow L: The cyclic relationship of natural illumination to cluster period frequency.
Cephalalgia 1987 , 7(Suppl 6):76-78.
Ekbom K: A clinical comparison of cluster headache and migraine.
Acta Neurol Scand 1970 , (Suppl 41):1+.
Russell MB: Cluster headache sine headache: two new cases in one family.
Cephalalgia 2002 , 22:1.
Salvesen R: Cluster headache sine headache: case report.
Neurology 2000 , 55:451.
May A, Bahra A, Buchel C, Frackowiak RS, Goadsby PJ: Hypothalamic activation in cluster headache attacks.
Lancet 1998 , 352:275-278.
May A, Ashburner J, Buchel C, McGonigle DJ, Friston KJ, Frackowiak RS, Goadsby PJ: Correlation between structural and functional changes in brain in an idiopathic headache syndrome.
Nat Med 1999 , 5:836-838.
Leone M, Franzini A, Bussone G: Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache.
N Engl J Med 2001 , 1428-1429.
Couturier EG, Hering R, Steiner TJ: The first report of cluster headache in identical twins.
Neurology 1991 , 41:761. PubMed Abstract
Roberge C, Bouchard JP, Simard D, Gagne R: Cluster headache in twins.
Neurology 1992 , 42:1255-1256. PubMed Abstract
Sjaastad O, Shen JM, Stovner LJ, Elsas T: Cluster headache in identical twins.
Headache 1993 , 33:214-217.
Svensson D, Ekbom K, Pedersen NL, Traff H, Waldenlind E: A note on cluster headache in a population-based twin register.
Cephalalgia 2003 , 23:376-380.
El Amrani M, Ducros A, Boulan P, Aidi S, Crassard I, Visy JM, Tournier-Lasserve E, Bousser MG: Familial cluster headache: a series of 186 index patients.
Headache 2002 , 42:974-977.
Leone M, Russell MB, Rigamonti A, Attanasio A, Grazzi L, D'Amico D, Usai S, Bussone G: Increased familial risk of cluster headache.
Neurology 2001 , 56:1233-1236.
Torelli P, Manzoni GC: Clinical observations on familial cluster headache.
Neurol Sci 2003 , 24:61-64.
Russell MB, Andersson PG, Thomsen LL, Iselius L: Cluster headache is an autosomal dominantly inherited disorder in some families: a complex segregation analysis.
J Med Genet 1995 , 32:954-956.
De Simone R, Fiorillo C, Bonuso S, Castaldo G: A cluster headache family with possible autosomal recessive inheritance.
Neurology 2003 , 61:578-579.
Rainero I, Rubino E, Valfre W, Gallone S, De Martino P, Zampella E, Pinessi L: Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis.
J Headache Pain 2007 , 8:152-156.
Epub 2007 Jun 2011
Rainero I, Gallone S, Rubino E, Ponzo P, Valfre W, Binello E, Fenoglio P, Gentile S, Anoaica M, Gasparini M, Pinessi L: Haplotype Analysis Confirms the Association Between the HCRTR2 Gene and Cluster Headache.
Headache 2008 , 48:1108-14.
Pinessi L, Rainero I, Rivoiro C, Rubino E, Gallone S: Genetics of cluster headache: an update.
J Headache Pain 2005 , 6:234-236.
Russell MB: Genetics in primary headaches.
J Headache Pain 2007 , 8:190-195.
Epub 2007 Jun 2011
Rigamonti A, Iurlaro S, Reganati P, Zilioli A, Agostoni E: Cluster headache and internal carotid artery dissection: two cases and review of the literature.
Headache 2008 , 48:467-470.
Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ: The clinical characteristics of headache in patients with pituitary tumours.
Brain 2005 , 128:1921-1930.
Epub 2005 May 1911
Irimia P, Cittadini E, Paemeleire K, Cohen AS, Goadsby PJ: Unilateral photophobia or phonophobia in migraine compared with trigeminal autonomic cephalalgias.
Cephalalgia 2008 , 28:626-630.
Boes C: Differentiating paroxysmal hemicrania from cluster headache.
Cephalalgia 2005 , 25:241-243.
Goadsby P, Lipton R: A review of paroxysmal hemicranias, SUNCT syndrome, and other short lasting headaches with autonomic features, including new cases.
Brain 1997 , 193-209.
Goadsby PJ: Trigeminal autonomic cephalalgias. Pathophysiology and classification.
Rev Neurol (Paris) 2005 , 161:692-695.
Matharu MS, Goadsby PJ: Trigeminal autonomic cephalgias.
J Neurol Neurosurg Psychiatry 2002 , 72(Suppl 2):ii19-ii26.
Cohen AS, Matharu MS, Goadsby PJ: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA) – a prospective clinical study of SUNCT and SUNA.
Brain 2006 , 129:2746-2760.
Williams MH, Broadley SA: SUNCT and SUNA: clinical features and medical treatment.
J Clin Neurosci 2008 , 15:526-534.
Rapoport AM, Bigal ME: Hemicrania continua: clinical and nosographic update.
Neurol Sci 2003 , 24(Suppl 2):S118-121.
Silberstein SD, Peres MF: Hemicrania continua.
Arch Neurol 2002 , 59:1029-1030.
De Simone R, Marano E, Ranieri A, Bonavita V: Hypnic headache: an update.
Neurol Sci 2006 , 27(Suppl 2):S144-148.
Carter DM: Cluster headache mimics.
Curr Pain Headache Rep 2004 , 8:133-139.
Favier I, van Vliet JA, Roon KI, Witteveen RJ, Verschuuren JJ, Ferrari MD, Haan J: Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases.
Arch Neurol 2007 , 64:25-31.
Leira EC, Cruz-Flores S, Leacock RO, Abdulrauf SI: Sumatriptan can alleviate headaches due to carotid artery dissection.
Headache 2001 , 41:590-591.
May A, Leone M, Afra J, Linde M, Sandor PS, Evers S, Goadsby PJ: EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias.
Eur J Neurol 2006 , 13:1066-1077.
Cohen AS, Matharu MS, Goadsby PJ: Trigeminal autonomic cephalalgias: current and future treatments.
Headache 2007 , 47:969-980.
Treatment of acute cluster headache with sumatriptan. The Sumatriptan Cluster Headache Study Group
N Engl J Med 1991 , 322-326.
Schuh-Hofer S, Reuter U, Kinze S, Einhaupl K, Arnold G: Treatment of acute cluster headache with 20 mg sumatriptan nasal spray – an open pilot study.
J Neurol 2002 , 94-99.
van Vliet JA, Bahra A, Martin V, Ramadan N, Aurora SK, Mathew NT, Ferrari MD, Goadsby PJ: Intranasal sumatriptan in cluster headache: randomized placebo-controlled double-blind study.
Neurology 2003 , 60:630-633.
Rapoport AM, Mathew NT, Silberstein SD, Dodick D, Tepper SJ, Sheftell FD, Bigal ME: Zolmitriptan nasal spray in the acute treatment of cluster headache: a double-blind study.
Neurology 2007 , 69:821-826.
Centonze V, Bassi A, Causarano V, Dalfino L, Cassiano MA, Centonze A, Fabbri L, Albano O: Sumatriptan overuse in episodic cluster headache: lack of adverse events, rebound syndromes, drug dependence and tachyphylaxis.
Funct Neurol 2000 , 15:167-170.
Paemeleire K, Evers S, Goadsby PJ: Medication-overuse headache in patients with cluster headache.
Curr Pain Headache Rep 2008 , 12:122-127.
Fogan L: Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation.
Arch Neurol 1985 , 362-363.
Kudrow L: Response of cluster headache attacks to oxygen inhalation.
Headache 1981 , 1-4.
Ekbom K, Paalzow L, Waldenlind E: Low biological availability of ergotamine tartrate after oral dosing in cluster headache.
Cephalalgia 1981 , 1:203-207.
Bussone G, Leone M, Peccarisi C, Micieli G, Granella F, Magri M, Manzoni GC, Nappi G: Double blind comparison of lithium and verapamil in cluster headache prophylaxis.
Headache 1990 , 30:411-417.
Leone M, D'Amico D, Frediani F, Moschiano F, Grazzi L, Attanasio A, Bussone G: Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo.
Neurology 2000 , 1382-1385.
Cohen AS, Matharu MS, Goadsby PJ: Electrocardiographic abnormalities in patients with cluster headache on verapamil therapy.
Neurology 2007 , 69:668-675.
Bartsch T, Goadsby PJ: Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater.
Brain 2003 , 126:1801-1813.
Epub 2003 Jun 1823
Ambrosini A, Vandenheede M, Rossi P, Aloj F, Sauli E, Pierelli F, Schoenen J: Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study.
Pain 2005 , 118:92-96.
Epub 2005 Oct 2003
Ashkenazi A, Levin M: Greater occipital nerve block for migraine and other headaches: is it useful?
Curr Pain Headache Rep 2007 , 11:231-235. PubMed Abstract | Publisher Full Text
Afridi SK, Shields KG, Bhola R, Goadsby PJ: Greater occipital nerve injection in primary headache syndromes – prolonged effects from a single injection.
Pain 2006 , 122:126-129.
Epub 2006 Mar 2009
Busch V, Jakob W, Juergens T, Schulte-Mattler W, Kaube H, May A: Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves.
Cephalalgia 2007 , 27:1206-1214.
Epub 2007 Sep 1210
Leone M, Dodick D, Rigamonti A, D'Amico D, Grazzi L, Mea E, Bussone G: Topiramate in cluster headache prophylaxis: an open trial.
Cephalalgia 2003 , 23:1001-1002.
McGeeney BE: Topiramate in the treatment of cluster headache.
Curr Pain Headache Rep 2003 , 7:135-138.
Reilly D: Lithium vs placebo in cluster headache.
Cephalalgia 1998 , 18:1.
Steiner T, Hering R, Couturier E, Davies P, Whitmarsh T: Double-blind placebo-controlled trial of lithium in episodic cluster headache.
Cephalalgia 1997 , 673-675.
Pascual J, Lainez MJ, Dodick D, Hering-Hanit R: Antiepileptic drugs for the treatment of chronic and episodic cluster headache: a review.
Headache 2007 , 47:81-89.
Leandri M, Luzzani M, Cruccu G, Gottlieb A: Drug-resistant cluster headache responding to gabapentin: a pilot study.
Cephalalgia 2001 , 21:744-746.
Schuh-Hofer S, Israel H, Neeb L, Reuter U, Arnold G: The use of gabapentin in chronic cluster headache patients refractory to first-line therapy.
Eur J Neurol 2007 , 14:694-696.
Hering-Hanit R, Gadoth N: The use of baclofen in cluster headache.
Curr Pain Headache Rep 2001 , 5:79-82.
Leone M, D'Amico D, Moschiano F, Fraschini F, Bussone G: Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups.
Cephalalgia 1996 , 16:494-496.
Pringsheim T, Magnoux E, Dobson CF, Hamel E, Aube M: Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study.
Headache 2002 , 42:787-792.
Hassenbusch SJ, Kunkel RS, Kosmorsky GS, Covington EC, Pillay PK: Trigeminal cisternal injection of glycerol for treatment of chronic intractable cluster headaches.
Neurosurgery 1991 , 29:504-508.
Pieper DR, Dickerson J, Hassenbusch SJ: Percutaneous retrogasserian glycerol rhizolysis for treatment of chronic intractable cluster headaches: long-term results.
Neurosurgery 2000 , 46:363-368.
Donnet A, Tamura M, Valade D, Regis J: Trigeminal nerve radiosurgical treatment in intractable chronic cluster headache: unexpected high toxicity.
Neurosurgery 2006 , 59:1252-1257.
Donnet A, Valade D, Regis J: Gamma knife treatment for refractory cluster headache: prospective open trial.
J Neurol Neurosurg Psychiatry 2005 , 76:218-221.
McClelland S 3rd, Barnett GH, Neyman G, Suh JH: Repeat trigeminal nerve radiosurgery for refractory cluster headache fails to provide long-term pain relief.
Headache 2007 , 47:298-300.
McClelland S 3rd, Tendulkar RD, Barnett GH, Neyman G, Suh JH: Long-term results of radiosurgery for refractory cluster headache.
Neurosurgery 2006 , 59:1258-1262.
Leone M, Franzini A, Broggi G, Bussone G: Hypothalamic deep brain stimulation for intractable chronic cluster headache: a 3-year follow-up.
Neurol Sci 2003 , 24(Suppl 2):S143-145.
Leone M, Franzini A, Broggi G, Bussone G: Hypothalamic stimulation for intractable cluster headache: long-term experience.
Neurology 2006 , 67:150-152.
Schoenen J, Di Clemente L, Vandenheede M, Fumal A, De Pasqua V, Mouchamps M, Remacle JM, de Noordhout AM: Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action.
Brain 2005 , 128:940-947.
Epub 2005 Feb 2002
Bartsch T, Pinsker MO, Rasche D, Kinfe T, Hertel F, Diener HC, Tronnier V, Mehdorn HM, Volkmann J, Deuschl G, Krauss JK: Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series.
Cephalalgia 2008 , 28:285-295.
Pinsker MO, Bartsch T, Falk D, Volkmann J, Herzog J, Steigerwald F, Diener HC, Deuschl G, Mehdorn M: Failure of deep brain stimulation of the posterior inferior hypothalamus in chronic cluster headache – report of two cases and review of the literature.
Zentralbl Neurochir 2008 , 69:76-79.
May A: Hypothalamic deep-brain stimulation: target and potential mechanism for the treatment of cluster headache.
Cephalalgia 2008 , 28:799-803.
Burns B, Watkins L, Goadsby PJ: Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients.
Lancet 2007 , 369:1099-1106.
Leone M, Franzini A, Cecchini AP, Broggi G, Bussone G: Stimulation of occipital nerve for drug-resistant chronic cluster headache.
Lancet Neurol 2007 , 6:289-291.
Schwedt TJ, Dodick DW, Trentman TL, Zimmerman RS: Occipital nerve stimulation for chronic cluster headache and hemicrania continua: pain relief and persistence of autonomic features.
Cephalalgia 2006 , 26:1025-1027.